17^th IHIWS/Immunogenetics Symposium: Sept 6–10, 2017
Conference: Sep 10, 2017

The 17th IHIWS will be held at Asilomar Conference Grounds, located in Pacific Grove, California. Lodging reservations should be made by going to the conference accommodations webpage at https://aws.passkey.com/event/49031649/owner/10793795/home. We recommend staying at or very near the event site in order to take advantage of all of the available activities and meals.

The registration fee covers all workshop sessions and coffee breaks on Wednesday-Sunday, opening reception on 9/6 and a strolling dinner reception on 9/9. Register to attend the event here: http://17ihiw.org/event-registration

The program includes a total of Six Symposia, International Immunogenetics Conference and International Histocompatibility and Immunogenetics Workshop (IHIWS) Activities.

Schedule and Program

Wednesday, September 6, 2017

15:00 – 19:00	Registration & check in
15:00 – 16:00	PM Coffee, Merrill Hall
18:00 – 19:00	Dinner, Crocker Dining Hall
19:00 – 20:00	Opening Ceremony, Merrill Hall
	Evolution of IHIWS, past and present Chair: Marcelo Fernandez-Vina, Stanford University Presidents: Derek Middleton, H&I Royal Liverpool Hospital, Steven GE Marsh, Anthony Nolan Research Institute In Memoriam Presentation by Frans HJ Claas for Johannes Joseph (Jon) Van Rood (1926-2017) Keynote Speaker: Walter F Bodmer, University of Oxford
20:00 – 21:30	Welcome reception: Light hors d’oeuvres, dessert & wine/beer, Merrill Hall

Thursday, September 7, 2017

07:30 – 08:30	Breakfast: Crocker Dining Hall
08:30 – 09:45	Symposium: Population Genetics, Merrill Hall Moderator: Marcelo Fernandez-Viña, Jill Hollenbach Symposium #S1a HLA Data-analysis: Challenges in the Era of NGS Steven Mack, Children’s Hospital Oakland Research Institute Symposium #S1b A genomic view of HLA variation Diogo Meyer, University of São Paulo, Brazil Symposium #S1c Population Genetics of HLA: in the era of NGS José Manuel Nunes, University of Geneva, Switzerland (for Alicia Sanchez-Mazas)
09:45 – 10:15	Morning Coffee break, Merrill Hall
10:15 – 12:00	Breakout Session #1a 10:15 – 12:00 Breakout Session #1a: Hackathon 10:15 – 12:00 Breakout Session #1a: HCT 10:15 – 12:00 Breakout Session #1a: Immunogenetics of Aging 10:15 – 12:00 Breakout Session #1a: KIR 10:15 – 12:00 Breakout Session #1a: SSBT 10:15 – 12:00 Breakout Session #1a: Epitopes 10:15 – 12:00 Breakout Session #1a: NGS HLA projects: CWD, Ref Panel, non-CWD
12:00 – 13:00	Lunch & Group Photo, Crocker Dining Hall
13:00 – 14:00	Symposium: Nomenclature and Disease Association, Merrill Hall Moderators: Erik Thorsby, Wolfgang R Mayr Symposium #S2a IPD-IMGT/HLA Database and extent of HLA diversity Steven GE Marsh, Anthony Nolan Research Institute Symposium #S2b HLA and Disease Association Henry A Erlich, Children’s Hospital Oakland Research Institute
14:00 – 15:45	Workshop-Activities, Merrill Hall Component: Bioinformatics Moderators: Martin Maiers, Steven Mack
14:00 – 15:00	17th IHIWS Database
14:00 – 14:20	Uniform HLA Data Collection and Storage Steven Mack/Chia-Jung Chang
14:20 – 14:35	Family Haplotype Analysis Kazutoyo Osoegawa
14:35 – 15:00	Methods for Population Analysis Python for Population Genetics (PyPop) — Steven Mack Bridging Immunogenomic Data Analysis Workflow Gaps (BIGDAWG) — Steven Mack Hapl-o-Mat — DKMS
15:00 – 15:15	Gene Feature Enumeration and Allele Calling Tool Mike Halagan
15:15 – 15:30	Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles James Robinson
15:30 – 15:45	STR sequencing through HLA genes Erik Rozemuller
15:45 – 16:15	Afternoon Coffee break, Merrill Hall
16:15 – 17:00	Breakout Session #1b 16:15 – 17:00 Breakout Session #1b: Family studies 16:15 – 18:00 Breakout Session #1b: NGS HLA projects: CWD, Ref Panel, non-CWD 16:15 – 17:00 Breakout Session #1b: Pharmacogenetics Project 16:15 – 17:00 Breakout Session #1b: Reference Panel 16:15 – 18:00 Breakout Session #1b: Epitopes 16:15 – 17:00 Breakout Session #1b: HCT 16:15 – 17:00 Breakout Session #1b: Hackathon
17:00 – 18:00	Breakout Session continued for Epitopes component
17:00 – 18:00	Workshop-Activities, Merrill Hall Component: NGS HLA Related Projects Moderators: Elissaveta Naumova, Marcel Tilanus
17:00 – 17:20	Extension of HLA allele sequences by full-length HLA allele-specific hemizygous Sanger sequencing (SSBT) Christien E Voorter
17:20 – 17:40	Immunogenetics of Aging Milena Ivanova
17:40 – 18:00	Disease Association Jorge Oksenberg
18:00 – 19:00	Dinner, Crocker Dining Hall
19:00 – 20:00	Symposium: Imputation & TCR, Merrill Hall Moderators: Dominique Charron, Elissaveta Naumova Symposium #S2c Imputation of HLA and KIR from GWAS Data Stephen Leslie, University of Melbourne Symposium #S2d Narcolepsy and TCR introduction Emmanuel Mignot, Stanford University
20:00 – 21:30	Breakout Session #1c 20:00 – 21:30 Breakout Session #1c: HCT 20:00 – 21:30 Breakout Session #1c: Hackathon 20:00 – 21:30 Breakout Session #1c: KIR 20:00 – 21:30 Breakout Session #1c: SNP based imputation of HLA alleles 20:00 – 21:30 Breakout Session #1c: TCR-HLA Interactions

Friday, September 8, 2017

07:30 – 08:50	Breakfast, Crocker Dining Hall
07:30 – 10:00	Breakfast (by invitation only), Woodlands Room WHO Nomenclature Committee for Factors of the HLA System Steven GE Marsh
09:00 – 10:00	Symposium: NGS HLA, Merrill Hall Moderators: J Alejandro Madrigal, Henry A Erlich Symposium#S3a Exploring HLA diversity by NGS in a registry population from Argentina Carolyn K Hurley, Georgetown University Symposium#S3b Allelic diversity and haplotype structure of 260 distinct full-length DPB1 sequences Gerhard Schöfl, DKMS gemeinnuetzige GmbH
10:00 – 10:30	Morning Coffee break, Merrill Hall
10:30 – 12:00	Workshop-Activities, Merrill Hall Component: NGS HLA Projects Moderator: Gottfried Fisher, Marcelo Fernandez-Vina
10:30 – 11:10	Workshop cell lines NGS HLA typing
10:30 – 10:45	Workshop Quality Control Diane De Santis, Sabine Wenda
10:45 – 11:00	Cell Lines NGS Workshop Report Lisa Creary
11:00 – 11:10	Single Molecule Real-Time (SMRT®) DNA sequencing of HLA genes at unambiguous, high-resolution from 126 International HLA and Immunogenetics Workshop cell lines Thomas Turner
11:10 – 12:00	IHIWS Registries report
11:10 – 11:20	Jurgen Sauter (DKMS)
11:20 – 11:30	Pablo Galarza (INCUCAI)
11:30 – 11:45	Yung-Tsi Bolon, Bob Milius (NMDP)
11:45 – 12:00	Whole-gene HLA class I nucleotide sequence variation and evolution among alleles from >100,000 individuals (Nezih Cereb)
12:00 – 13:00	Lunch, Crocker Dining Hall
13:00 – 15:15	Breakout Session #2a 13:00 – 15:15 Breakout Session #2a: Hackathon 13:00 – 14:30 Breakout Session #2a: HCT 13:00 – 15:30 Breakout Session #2a: Epitopes
13:00 – 15:15	Workshop-Activities, Merrill Hall Component: NGS HLA Projects, Population Genetics Moderators: José Manuel Nunes, Steven Mack
13:00 – 13:20	CWD Summaries Carolyn Hurley, Jason Dehn
13:20 – 13:35	Dual redundant reference sequencing: characterizing diversity Irina Böhme
13:35 – 13:50	Rare & Novel HLA Alleles by NGS HLA — Coding non-coding polymorphism Medhat Askar
13:50 – 14:30	IHIWS Families project contributors, individual brief reports
14:30 – 15:15	IHIWS Unrelated project contributors, individual brief reports
15:15 – 15:45	Afternoon Coffee break, Merrill Hall
15:45 – 16:45	Workshop-Activities, Merrill Hall Component: NGS HLA Family and unrelated studies Summaries Moderators: Dominique Charron, Carolyn Hurley
1545 – 1615	Haplotypes in Families Report Kazutoyo Osoegawa, Medhat Askar
1615 – 1645	Unrelated Population Analysis Report Marcelo Fernandez-Vina
16:45 – 18:15	Breakout Session #2b 16:45 – 18:15 Breakout Session #2b: Hackathon 16:45 – 18:15 Breakout Session #2b: Epitopes
16:45 – 17:45	Symposium: NGS KIR, Merrill Hall Moderators: Daniel E Geraghty, Mary Carrington Symposium #S4a NK cell receptor interactions with their MHC class I Ligands Andrew Brooks, University of Melbourne Symposium #S4b KIR about the World Paul Norman, Stanford University
17:45 – 18:15	Workshop-Activities, Merrill Hall Component: NGS of Full-length KIR Genes Moderator: Paul Norman Analysis and results KIR Component projects, overview Jill Hollenbach
18:15 – 18:45	Sponsor Presentations: #1 – One Lambda #2 – Illumina
18:45 – 19:45	Dinner, Crocker Dining Hall
19:45 – 21:30	Wine Tasting: A Taste of Monterey, Sea Scape Room Sponsored by One Lambda, a Thermo Fisher Scientific Brand

Saturday, September 9, 2017

07:30 – 08:50	Breakfast, Crocker Dining Hall
07:30 – 08:50	IHIWS Councilors Breakfast Meeting, Woodlands Room (By Invitation Only) Chairs: Derek Middleton and Steven GE Marsh, IHIWS PresidentsAgenda: 18th IHIWS/Next venue proposals (10 min each) selected from submission proposals Overview of current IHIW Council and Pre-nominations for new councilors
09:00 – 12:00	Symposium: Hematopoietic Cell Transplantation (HCT), Merrill Hall Moderators: Effie W Petersdorf, Carlheinz Muller
09:05 – 10:00	Symposium #S5a
09:05 – 09:15	IHWG Study of the Role of Ethnicity in HLA-mismatched HCT Yasuo Morishima, Aichi Medical University
09:15 – 09:25	French study about effect of DRB and DPB1 mismatches on outcome after HSCT Valerie Dubois, EFS Auvergne Rhone Alpes
09:25 – 09:35	JMDP HLA-DP study update Satoko Morishima, University of the Ryukyus
09:35 – 09:45	Biological mechanisms controlling alloreactivity to HLA-DP Esteban Arrieta Bolaños, Institute for Experimental Cellular Therapy
09:45 – 10:00	Panel discussion
10:00 – 10:30	Morning Coffee break, Merrill Hall
10:30 – 12:00	Symposium #S5b
10:30 – 10:50	The impact of definitive HLA typing on unrelated donor hematopoietic stem cell transplant outcome – Does TGS typing make a difference? Neema Mayor, Anthony Nolan Research Institute
10:50 – 11:10	Role of KIR in Transplantation Katharine Hsu, Memorial Sloan Kettering Cancer Center
11:10 – 11:20	Effect of MICA and HLA-E in HSCT: Results of a German Cohort Joannis Mytilineos, Institute of Transfusion Medicine (IKT)
11:20 – 11:30	Role of MICA – The US Experience Medhat Askar, Baylor University Medical Center
11:30 – 11:40	MICA and GVHD Seiamak Bahram, Université de Strasbourg
11:40 – 12:00	Panel discussion
12:00 – 13:00	Lunch, Crocker Dining Hall
13:00 – 14:00	Symposium: Solid Organ Transplant, Merrill Hall Moderators: Rhonda Holdsworth, Narinder Mehra Symposium #S6a Immunogenicity and structural characterization of antibody epitopes Frans HJ Claas, LUMC Symposium #S6b Computational modelling of HLA structure and electrostatics in transplant immunology and histocompatibility Vasilis Kosmoliaptsis, University of Cambridge
14:00 – 15:30	Workshop-Activities, Merrill Hall Component: Mapping of Serologic Epitopes Moderators: Dolly Tyan, Frans HJ Claas
14:00 – 14:05	What is an epitope? Frans HJ Claas
14:05 – 14:25	Brazil Analysis Semiramis Jamil Hadad do Monte
14:25 – 14:45	Netherlands Analysis Sebastiaan Heidt, Cynthia Kramer
14:45 – 15:05	Stanford Analysis and Automation of Donor Specific Antibody Assignment and Virtual Crossmatching Chia-Jung Chang and Dolly Tyan
15:05 – 15:15	PIRCHE for T cell help Eric Spierings
15:15 – 15:25	Variations in cell surface expression and stability among HLA-B antigens Malini Raghavan
15:25 – 15:30	Epitope Nomenclature – Where do we go next?
15:30 – 16:00	Afternoon Coffee break, Merrill Hall
16:00 – 16:45	Sponsor Presentations: #3 – HistoGenetics: Inherited and non-inherited structural variations observed with whole genome sequencing (Nezih Cereb) #4 – Immucor #5 – DKMS: The Quest for the Optimal Donor Profile
16:45 – 17:15	Going to the Future: HLA Genomics Moderators: Martin Maiers, John TrowsdaleGenomics of MHC micro RNA Dimitri Monos, The Children’s Hospital of Philadelphia
16:45 – 17:00	Genomics of MHC micro RNA Dimitri Monos, The Children’s Hospital of Philadelphia
17:00 – 17:15	Full Characterization of Human MHC and KIR haplotypes and genotypes by de Novo whole genome sequencing on PacBio Sequel platform Nezih Cereb, HistoGenetics
17:15 – 17:35	Marcelo Fernandez-Vina, Stanford University, Workshop remarks, Merrill Hall
17:35 – 18:30	Breakout Session #3a 17:35 – 18:30 Hackathon 17:35 – 18:30 HCT 17:35 – 18:30 Epitopes
19:00 – 22:00	DINNER CLOSING RECEPTION, Asilomar Meadow/ Bar-B Que Area Music by Wild Blue Quartet Strolling Dinner, Includes wine/beer/soda

Sunday, September 10, 2017

08:00 – 12:00	Checkout
07:30 – 08:30	Breakfast, Crocker Dining Hall
08:30	17th IHIWS Summaries, Merrill Hall Moderators: Derek Middleton, Gottfried Fischer
08:30 – 08:50	Informatics and Population Genetics Steve Mack, Children’s Hospital Oakland Research Institute
08:50 – 09:20	HLA typing by NGS Marcelo Fernandez Vina, Stanford University
09:20 – 09:40	17th IHIWS KIR Component QC and Sample Collection results Cynthia Vierra-Green, CIBMTR Jill Hollenbach, UCSF
09:40 – 10:10	Epitope Analyses Dolly Tyan, Stanford University Frans HJ Claas, LUMC
10:10 – 10:30	Immunogenetics of HSC Transplantation Effie W Petersdorf, Fred Hutchinson Cancer Research Center
10:30 – 11:00	Morning Coffee break, Merrill Hall
11:00 – 12:00	Immunogenetics Conference Moderators: Steven GE Marsh, Marcel GJ Tilanus
11:00 – 11:30	C1-Immunogenetics Conference, Merrill Hall The industrial revolution of the MHC John Trowsdale, University of Cambridge
11:30 – 12:00	C2-Immunogenetics Conference, Merrill Hall HLA Diversity Marcelo Fernandez-Viña
12:00 – 13:00	Lunch, Crocker Dining Hall
13:00 – 15:00	Immunogenetics Conference Moderators: Dominique C Charron, Clara Gorodezky
13:00 – 13:30	C3-Immunogenetics Conference, Merrill Hall Antigen Presenting Structures James McCluskey, University of Melbourne
13:30 – 14:00	C4-Immunogenetics Conference, Merrill Hall Elevated HLA-A expression impairs HIV control through increased natural killer cell inhibition Mary Carrington, Leidos Biomedical Research Inc.
14:00 – 14:30	C5-Immunogenetics Conference, Merrill Hall KIR and HLA interactions Peter Parham, Stanford University
14:30 – 15:00	C6-Immunogenetics Conference, Merrill Hall HLA as predominant genetic factors for autoimmune diseases, infectious diseases, and adverse drug reactions Katsushi Tokunaga, University of Tokyo, Graduate School of Medicine
15:00 – 15:30	Afternoon Coffee break, Merrill Hall
15:30 – 16:30	Immunogenetics Conference Moderators: Steven GE Marsh, Walter F Bodmer
15:30 – 16:00	C7-Immunogenetics Conference, Merrill Hall Histocompatibiity testing for organ transplantation: Present and Future Frans HJ Claas, LUMC
16:00 – 16:30	C8-Immunogenetics Conference, Merrill Hall Immunogenetics of Allogeneic Hematopoietic Cell Transplantation Effie W Petersdorf, Fred Hutchinson Cancer Research Center
16:30 – 17:00	Closing Remarks by Chair: Marcelo Fernandez-Vina, Stanford University
17:20	Bus Transport to San Francisco general
17:20 – 18:20	Bus Transport to Councilor’s dinner & SF
18:20 – 20:30	IHIWS Council Members Dinner, PortaBella Restaurant (By Invitation Only) Website: http://portabellacarmel.com James McCluskey Moderator, Agenda to be defined by current Presidents Voting to select 18th IHIWS Voting councilor’s selection